Rheumatoid arthritis is an autoimmune condition in which the body's immune system attacks the joints, causing inflammation that presents as joint pain, swelling, and stiffness, and may lead to lasting damage. While there is, unfortunately, no cure for rheumatoid arthritis, there are ways to manage the symptoms by reducing inflammation. In recent years, turmeric has gained popularity in popular culture as a potential anti-inflammatory treatment, but does the science back this up? In this article, we’ll explore the research being done to determine if turmeric really can reduce inflammation, as well as ways to incorporate turmeric into your diet to help you reduce inflammation naturally.
What Is Turmeric?
It may seem as though turmeric has just recently entered popular culture, but this golden yellow spice has actually been used in traditional medicine for centuries. Turmeric comes from the root of the Curcuma longa plant, which is a member of the ginger family. It contains a compound called curcumin that has been shown to have anti-inflammatory properties. Turmeric is commonly used in Chinese, Indian, and Japanese medicines, but is growing in popularity in Western natural medicine. (Source)
Does Turmeric Reduce Inflammation?
Given the popularity and long history of turmeric use, a fair number of studies have investigated whether this spice actually reduces inflammation. Many of these studies have been in animals or laboratory cell cultures, but we’re most interested in knowing how curcumin works in humans. To evaluate the evidence of turmeric’s purported anti-inflammatory effects, we’ll look at a few meta-analyses, which systematically collect and combine data from several previously published studies to find common trends in their conclusions.
Meta-Analysis #1
A 2021 meta-analysis looked at the effects of supplementation with curcumin, the active ingredient in turmeric, on patients with rheumatoid arthritis and ulcerative colitis. Six randomized controlled trials (the gold standard for research studies) were included in the meta-analysis. The researchers found that patients with rheumatoid arthritis who took curcumin supplements in doses of 250 mg to 1500 mg per day over 8–12 weeks had decreased inflammation compared to patients who did not take the supplements. A longer duration and larger dose were both associated with a greater decrease in inflammation. (Source)
Meta-Analysis #2
A different meta-analysis from 2022 looked at randomized controlled trials that investigated curcumin and Curcuma longa extract as a treatment for 10 types of autoimmune diseases. The study found that, in the 5 trials that specifically looked at rheumatoid arthritis, curcumin decreased a marker of inflammation called C-reactive protein and improved disease activity overall. (Source)
Meta-Analysis #3
Another meta-analysis looked at how effective and safe curcumin was for treating symptoms of arthritis. The analysis included clinical studies on patients with rheumatoid arthritis, as well as ankylosing spondylitis, osteoarthritis, juvenile idiopathic arthritis, and gout/hyperuricemia. Doses of curcumin ranged from 120 mg to 1500 mg, and patients took curcumin for anywhere from 4 to 36 weeks. The researchers found that, in general, curcumin decreased inflammation and pain levels in patients with arthritis and was safe to take for this purpose. (Source)
Studies Conclude Turmeric Helps
So, when we look at the findings from these meta-analyses of clinical trials, the science does suggest that the curcumin in turmeric can have anti-inflammatory effects in people with rheumatoid arthritis, as well as other types of autoimmune conditions. Ideally, we would like larger high-quality studies to confirm these results, but the majority of available evidence suggests turmeric can reduce rheumatoid arthritis symptoms.
How Does Turmeric Reduce Inflammation?
Inflammation is the body’s natural response to injury or infection, but when it becomes chronic, it can lead to a range of health problems, including rheumatoid arthritis. The curcumin in turmeric is thought to reduce this inflammation by blocking the production and action of proinflammatory cytokines, which are proteins that play a key role in the development and disease progression of rheumatoid arthritis. By blocking these proinflammatory cytokines, the inflammation and related arthritis symptoms are decreased. (Source, Source)
Turmeric Is Also an Antioxidant
Another way curcumin may reduce inflammation is through its ability to act as an antioxidant. Antioxidants are substances that protect your cells against free radicals — molecules with an unpaired electron in their outer orbit that makes them unstable and reactive. Your body has natural defenses against damage from free radicals, known as oxidative stress, but curcumin can support your natural defenses by providing additional antioxidant support. As oxidative stress can also increase inflammation, by acting as an antioxidant turmeric can also indirectly reduce inflammation. (Source, Source)